The Department recently looking for PromethION 24 DNA/RNA Sequencer to support research in epigenetics, microbial ecology and DNA/RNA base modification analysis. Oxford Nanopore Technologies(ONT) is the only supplier that meets the specific technical and research requirement of this project. ONT’s native sequencing technology enables comprehensive detection of DNA and RNA base modifications, including 5mC, 5hmC, 4mC, and 6mA, as well as native RNA sequencing. These capabilities are essential to the epigenetics research program. The adaptive sampling capability allows sequencing to be monitored and selectively enriched or excluded in real time, providing significant advantages for targeted genomic and microbiome research. ONT holds the patents for its sequencing technology and is the sole manufacturer and supplier of the required sequencer, reagents, flow cells, and associated software, as well as the manufacturer’s warranty. Therefore, compatible products and services cannot be sourced from alternative suppliers. Based on the unique technical requirements of the research I will recommend Oxford Nanopore Technologies.