The objective of the work is to engage space exploration topical teams to produce a consensus report that can inform decision-making on the future of the space exploration program via community-led consultation prioritizing Canadian science activities and investigations based upon scientific merit, importance to the community and benefits to Canada. The Topical Teams will identify discipline scientific priorities, opportunities and steps needed to incorporate these into space exploration missions. In particular, this should include a detailed update of the 2016 Canadian Space Exploration: Science and Space Health Priorities for the Next Decade and Beyond report while integrating the latest developments in knowledge, research and recommendations from the science, health and space exploration communities since its publication in 2017. As a science-driven document, the resulting updated report will be used as an input for Canada’s strategic planning for future space exploration initiatives with activities beginning as early as 2024 and spanning up to a 2050 horizon.